` L^ana8 aaaa>aaaa6aaHaa>09"|g@| gh|pgb| SgVAP2k̰g`IAIAf pC""""aXJyg8 a0a`aBgNA/8NuJy fr y x@ y3 `PJy$f8p yjA^#AnCڊ"23$A&C0<cQAڊSy$Nu 9|#|Nu5K n$y\J\M~AH<<caPHQNu0(r2("J(M24(JAf"HAP@|m 1G1ANu1@i1ANuQ1ANuBEMH><c<E@?<NNTOH@@>>>xfxfx&`ǀ>>>>xfxfx&`ǀ>>>>x333<?3<0>>>>x>>>>333<?3<0>>>>0>>>>ff٘>>>>0>>>>ff٘>>>>0>>>>ff٘>>>>0<< lp>>>><  >>>>????88????>>>>????????????`>>>>`????`????~~~~>>>>`????~~~~????>>>>>>>>s|`}||>>>>>>>>????//>>>>>>>>{|`}||>>>>>>>>>>>/>>>>>>>>{`>>>>>>>>>>>/>>>>>>{>>`>>>>>>>>>>>/>>>>>3>> >0>>>>>>>>>>>o????>>>>????>3>> >0>>>>>>>>>>>/>>>>>3>> >0>>>>>>>>>>>o>3>> >0>>>>>>>>>>>/>3>> >30>>>>>>>>>>>/>3>> >30>>>>>>>>>>>>3>> >0????>>>>>>>>>>>3 0>>>>>>>>>>>3 0>>>>>>>>>>>????3 0>>>>>>>>>>>>>>>3 0>>>00 3030303<3030303<f`30303< ?30303131313111113<30303030303000003<ff3030333300003<<<30303 3 3 3 00003<xx3030333300003<f`xxf`33330000fx ?xxf`3#3#3#3#1111&f8x?33xxf`&f8x?ff<< lp<<ff٘xx333<?3<0xx333<?3<030fxfx&`ǀ30 ?l30 ـ30 xxxxxx313011f`3<?&830 ;;;fxlp30 `?`?`?   30 `.`.tt /tt30 $$$$$$``̀$$$3 30 f`30 ` `  xx ` ` ` xxxxxx0<<`33<?f`330f`fyf`f` ?3 ?fx ?3333<>>333303<3011333333``303<30000333333333```303<30`0`0`0333333333```303<f` `0`0333333303<f` 0003>3>3>333```303<f` 0003030303```3< ?`1`137303``&f8x? ?xxx```4303```&f8x?&f8x? ?&f8x? ?&f8x? ?lp ?٘٘٘033&`ǀ33&`ǀ3333ffxx&`ǀ3333ffxxl3333ffxx ـff33ffxx ـff33ffxx ـff33ffxxff33ffxx3<?&8ffff33<>>>fn`3<fxlp<<ffCC 3030fn`3<0000F F <<ffCC  3030n`3<0000L L <<ffCC  3030nz`x3<1100 <<CC  3<3<n`aa3<003030<<ff  3030nz`x113<113131 003 <<ff  3030n`3<003131 ``3 <<ff 3030f``3<003232 3 <<ggCC>>>>f||3<<<f3<$$~$~$|||D DD((D||||8p||8x88||||BhB(RB(VSh|mLx>J(/g\J(Rf2J(Vg0(`@RhS(VBh`BhSR[a[V[[f[m`Th[m[j[k!K>S(R(m<b(%(:jp@mJ(7g4J(Tf"J(Xg0(d@TS(X` UT]e]X]P!MFS(TJ(3gJ(Sf$J(Wg0(b@S@S(W` TS\c\W8!LBS(SvJDk2CK 0("J(*f((P@65D41@~ 1Ch`RCtK 0("J(*f((P@65DDD41@~ 1Ch`K 0("J(*f((P@1uh6(h<(Ng"JhgSh`>(n~ 1FN1ChJ(;g4J(Uf"J(Yg0(f@US(Y` VU^g^Y^!NJS(UShNuB9LLAXJ(kJ(kJ(fJ(Qg !`6(h ( g((m<c:<g"4(ZkhjB8ÈKÈ!`(4(ZkB8ÈKÈAPJ(fJ(Qg ! `6(h ( g((m<c<<g$4(ZkhjÈKÈ! `* 4(ZkÈKÈATJ(fJ(Qg ! `6(h ( g((m<c<<g$4(ZkhjÈKÈ! `* 4(ZkÈKÈJg* ƈN ƈM>g  ňJk ĈCJQgB9p#iSQNuB8Bk!@RNsRNs@F'A|    8B9C!!FNu@B9F'A! FNuMJfK f MNuRSNuMJfKJf MNuSSNuNqAt.ߘ PfA Pg,XJgߐXJgߐXJgߐXJgߐXJgߐP`A0r"X Qg QgߑC `QA Pg4XJgߐXJgߐXJgߐXJgߐXJgߐ PfACX"AC"AC"!@A,C>"AFCJ"ATCJ"A `<c0!!! ! Ax0Nu#NuAh0Nq A Nu1Q 1YL<.H<>Nu1h 1Y"L<.H<>Nu1h 1Y$L<.H<>Nu1h 0(f(HE $rL>H>*H<>Nu1Q 1Y1Y"L<.H<>Nu1Q 1Y1Y$L<.H<>Nu1Q 1Y0(f(HE 0$rL>H>*H<>Nu1h 1Y"1Y$L<.H<>Nu1h 1Y"0(f(HE$rL>H>*H<>Nu1Q 1Y1Y"1Y$L<.H<>Nu1Q 1Y1Y"0(f(HE$rL>H>*H<>Nu1Q 1YL<.H<>1Y" Yf$E,02( 41BB@1rn1| NNuE02( 41BB@1rn1| NNu1h 1Y"1Y$0(f(HE$rL>H>*H<>Nu1Q 1Y1Y"1Y$0(f(HE$rL>H>*H<>Nu|Q1Q 1YL<.H<>Nu0(f(HEx&rJ(g 1Q 1YXNu1k\1Q 1Y0g"E|!:@ %k1Y^NuJ(fE%k|!1Y^Nu % h  o LHa47c${IvS1vaM;) }voic]XSNJFB>;741.,)'%#! ~}{zyxwvtsrqpomlkjihfedcba`^]\[ZYWVUTSRPONMLKJHGFEDCA@?>=<:987654210/.-,*)('&%#"!     ~}|{zyxvutsrqpnmlkjihgfdcba`_^][ZYXWVUTRQPONMLKIHGFEDCBA?>=<;:9865                       ! " $ % & ' ( * + , - . / 1 2 3 4 5 7 8 9 : ; = > ? @ A C D E F G H J K L M N P Q R S T V W X Y Z \ ] ^ _ ` b c d e f h i j k l n o p q r t u v w x z { | } ~ !!!!!!!!! ! ! ! !!!!!!!!!!!!!!! !!!"!#!%!&!'!(!)!+!,!-!.!0!1!2!3!5!6!7!8!9!;!!@!A!B!C!D!F!G!H!I!K!L!M!N!P!Q!R!S!T!V!W!X!Y![!\!]!^!`!a!b!c!e!f!g!h!i!k!l!m!n!p!q!r!s!u!v!w!x!z!{!|!}!~!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!f X<p xt8p , ,VVVVV, PPPP@ 0 0 0 0 0 0 0 0 0 0>t >t >  >  >t >t >  >  >t >t >  >  >t >t >  >>>t >t >  >  >t >t >  >  >t >t >  >  >t >t >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> < @< @: @? @<                      `< `F `C `F `A 0C A ? <  " ( . 4 :  8 ^ F ^ D d ^ F d  N F T @ T; -  ****  8 P               <Z<xxP`` <Z<                                                                                                                   S,%43'/0%23)34%.#%/&6)3)/.02%3%.43$)3#2%,%!3%$!4%!02),!,,#/$%"9-!#393$!4!'2!&)8"9-!#393$!4!-53)#"9,/4533/)3!)$4/4(%'597)4(4(%,/.'.%#+')2!&&%4/4()3)3-!#393$!4!/54/&4(%!39,5-!4,!34!.$/.4/!+%9"/!2$./7!9-!.).!7()4%#/!4)-&2%%#!.9/52%!$4()3./4(%.4/5'()7!33)44).'4(%2%/.4(%"/'05::,).'/6%2,)&%).'%.%2!,7(%.)(!$!&,!3(/&).30)2!4)/./.#%"!#+/.-934%)34!24%$72)4).')$%!3$/7."%&/2%)&/2'/44(%-(/523/&#/$).'!.$)47!3$/.% 4(%2!34%23#2/,,%2)&9/5%6%27/.$%2%$(/74()37!3$/.%4(%.05::,%/6%2)4./-/2%#!53%),,4%,,9/5,!4%2/.4()3$)3#7!3'/).'4/"%!4#"42!#+%2"544(%$!-.4().'+%04'/).'72/.'%6%.4(/5'()/.,953%$4(%2%')34%23)7!33500/3%$4/7%,,/.#%!'!).4(%0/6-!#().%(!334!24%$50!.$)%80%#4!,,4(%0$,)"2!2)%37),,"%',!$4/(!6%2%#%)6%$3/-%.%7-%.53)(/0%4/3%%3/-%/&4(%.%7-%.53!$6%24)3%$3//.)(/0%%6%29/.%(!3'/44(%34&/2-!47)4(#/6%2$)3#/.!3)4(!3!$%-/#/09/&,%!.$%27()#("/2)3/&0/672/4%)&9/5!2%#,%6%2%./5'(9/5#!.$%0!#+4(%#/$%7)4()#%/.#%$%0!#+%$9/57),,3%%!-%33!'%02/6).'(%#/$%$)42)'(4(%2%#/-%34(%'2%%4).'3()4/"!24 $%, -!24)!. "),"/ -5'5+ 30%%$ $%,4!&/2#% !$2%.!,). $239.% )..%2#)2#,% %2)+0,!.+4/.!.$",).$"!34!2$ ./7 54/3 4(%%.4%202)3% %,%#42/.)# +'" 4(%&/2#% 0)8%,47).3 ./$ :/''!.$4(%7!4#(-%. 3%7%23/&47!2% %-0)2% &!#4/29 2%0,)#!.43 %4%2.!,$%6%,/0-%.4 (!00%.).'"/): /89'%.%#2%7 '%.%3)3).# -!$6)3)/. #9.)8 (/4,).%-#! $%,)'(4 !,4!)2!.$-28)&9/52%./4/.-9'2%%4).'3,)34!.$(!6%2%'5,!2#/.4!#44(%.'%4).4/5#(!.$#/-0,!).7(),34)2%-%-"%2)7/5,$,)+%4/4%,,%6%29/.%!"/54"!4(""3)53%$4/,/'/.4/4()35.4),)47%.44/!35"3#2)04)/."54),/''%$/.2%#%.4,94/(!6%!,!5'(7(),34-%33).'!2/5.$)./4)#%$)4(!3'//$-!.0$,,)34/.!.$9/5#!.,%!6%!-%33!'%&/234 &/2-!4)$)$.4"54)7!34%-04%$4/(!6%!'/!4-2'//$-!.7%34),,(!6%.4&/2')6%.9/5&/2"!..).'0/6$)3#3 )6%"%%."5390(/.).'-!.9""3,!4%,9&2/-7/2+).-9$)..%2(/52)53%4(%7/2+3!54/ $)!,%2!.$$/7.,/!$3/&47!2%4/-90#!&4%20544).')4/.).#($)3#3),/!$)4/.-934%!.$$%0!#+)4)6%(!$!"/54-%'/&345&&3/&!2!.$4(%2%)30,%.494/'/4(%/.,902/",%-)34(!4!4")430%23%#/.$)4)302%4493,/7./4%)3!)$"03./4"!5$ )7)3(-/2%/&4(%""3(!$#/-02%33)/.-/$%-3!39/5#!.'%4!()'(%24(2/5'(054!44(%3!-%30%%$ )&9/5(!$.4'5%33%$ )-!.%47/2+30%#)!,)347(/&)8%3&!5,43/."/4(4(%$!4!!.$6/)#%#)2#5)43(%9&/5.$!4)/.""3 ),)+%9/52"/!2$"54)44!+%34//,/.'4/'/4(2/5'(9/52,)34/(9%!(7(),34)2%-%-"%2 (%9254(,%33!3+-%-"%23/&!$2%.!,).7(!44(%97%2%#!,,%$"%&/2%4(%9*/).%$!$2%.!,).2)'(44()3)34(%%.$3/'/!(%!$!.$25.!$%-//+!9!,,4(%,!-%233(/5,$(!6%'/.%3/),,%80,!).4(%4%#(.)15%/&4(%3#2/,,%2&)234$%&).%!0)#452%7)4($)&&%2%.4"!.$3/&#/,/52'/).'6%24)#!,,9504(%3#2%%../7$%&).%!&/.40)8%,37)$%/+!94()3)34(%#,%6%2")472)4%!3#2/,,2/54).%4(!453%3!,).%"5&&%2./73%4504)-%2"(", 4/4%34%!#(")4/&4(%"94%).4(%"5&&%234!24!44(%-/343)'")4!.$7/2+$/7.4/4(%,%!343)'")49/53(/5,$"%4%34).'4(%")434(!4-!+%504(%,%44%23/7(%.9/54%34!")4!.$4(%2%35,4)3:%2/",!.+ 4(%.$%&).%/.%/&4(%#/,/523).4(%6%24)#!,"!.$3",!#+)&4(%2%35,4)30/3)4)6%4(%.$%&).%/.%/&4(%#/,/5233/9/5#!.3%%)4$/4()3&/24(%3%6%.")43!.$9/53(/5,$3%%!0)8%,,).%!00%!27)4(3/-%#/,/522%0%!44()302/#%33/&4%34).'4(%")43&/2%6%29,).%/&4(%3#2%%.!.$4(%7(/,%"5&&%23(/5,$!00%!2!3#(!2!#4%233(/7.7(%2%4(%6%24)#!,#/,/52"!.$3!2%%6%296",-/6%4(%"5&&%250/.%"94%!.$054!.%7&/.4"94%!44(%"5&&%2%.$9/57),,02/"!",9&).$4(!44(%4%34).'2/54).%4!+%315)4%3/-%4)-%!.$3/9/57),,02/"!",9%.$504%34).'4(%")43%6%296%24)#!,,).%3)&9/5#!.45.$%234!.$4(%02).#)0,%4(%.,//+/54/.4(%0$3#%.%).!"/54-/.4(34)-%!3)7),,"%2%,%!3).'4(%3/52#%#/$%&/2!,,4/3%%mnojkzقَٚٞMM.MEGillumina.1illumina.2dmacopier.povF*      b,0         $